The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease
Academic Article
Publication Date:
2018
abstract:
Cholinergic dysfunction is a key abnormality in Alzheimer disease (AD) that can be detected in vivo with transcranial magnetic stimulation (TMS) protocols. Although TMS has clearly demonstrated analytical validity, its clinical utility is still debated. In the present study, we evaluated the incremental diagnostic value, expressed in terms of diagnostic confidence of Alzheimer disease (DCAD; range 0-100), of TMS measures in addition to the routine clinical diagnostic assessment in patients evaluated for cognitive impairment as compared with validated biomarkers of amyloidosis.
Iris type:
1.1 Articolo in rivista
Keywords:
Alzheimer disease; Confidence; Diagnosis; Frontotemporal dementia; PET amyloid; Transcranial magnetic stimulation; Aged; Alzheimer Disease; Amyloidosis; Biomarkers; Brain; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Sensitivity and Specificity; Transcranial Magnetic Stimulation
List of contributors:
Benussi, Alberto; Alberici, Antonella; Ferrari, Clarissa; Cantoni, Valentina; Dell'Era, Valentina; Turrone, Rosanna; Cotelli, Maria Sofia; Binetti, Giuliano; Paghera, Barbara; Koch, Giacomo; Padovani, Alessandro; Borroni, Barbara
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