Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet

Background and Objectives: In this study, the effects of an eight-week exercise and nutrition
program on blood lipids, glucose, insulin, insulin resistance (HOMA-IR), leptin, ghrelin, irisin,
malondialdehyde (MDA), and Growth Differentiation Factor 15 (GDF15) in overweight women were
investigated. Materials and Methods: A total of 48 women volunteers participated in this study. The
participants were randomly divided into four groups: control (C), exercise (E), nutrition (N), exercise
+ nutrition (E + N). While no intervention was applied to group C, the other groups participated in
the predetermined programs for 8 weeks. At the beginning and end of this study, body composition
was measured and blood samples were taken. Results: It was determined that the body composition
components, lipid profile indicators, insulin, glucose, insulin resistance, leptin, ghrelin, irisin, and
MDA parameters examined in this study showed positive changes in the intervention groups. Group
E had a greater effect on body muscle percentage, MDA, and irisin levels, while group N had a
greater effect on blood lipids and ghrelin levels. Conclusions: As a result, it is thought that lifestyle
changes are important to improve cardiovascular health and combat obesity, and that maintaining a
healthy diet together with exercise may be more effective.