Annotating omics Data with sex and age of samples: Enabling powerful omics studies

There is increasing evidence that many molecular processes exhibit differences with age and sex. Such differences produce also differences in the insurgence and progression of many complex diseases. For instance, demographic data on the insurgence of comorbidities of mellitus diabetes, on the lethality of COVID-19, and on some cancers shows differences between sex and age groups. Therefore, the growing interest in such areas requires the management of related data as well as the development of algorithms and tools for the analysis. The availability of omics data annotated with metadata related to age and sex is mandatory for building the analysis pipeline. The number of databases containing data related to age and sex is henceforth growing. We here show some databases and tools storing such data. Finally, future research directions are highlighted.